Sea cucumbers (SCs) are a high-value seafood in Southeast Asia, prized for their nutritional and health benefits. The Atlantic species Cucumaria frondosa is particularly noted for its biological and pharmacological properties, including anticancer effects and benefits for hyperglycemia, inflammation, Alzheimer's, aging, and stress (Al Shemaili et al., 2016; Attoub et al., 2013; Liang et al., 2022; Ma et al., 2012; Tangrodchanapong et al., 2020). Its compounds, including eicosapentaenoic acid (EPA), saponins, and chondroitin sulfate, aid in diabetes treatment by reducing serum glucose and improving insulin resistance (Han et al., 2019; Zhang et al., 2020).

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